Innovationsportal Sachsen-Anhalt

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Kurt-Mothes-Straße 3


Halle (Saale)

Tel.:+49 345 5524983

Jun.-Prof. Dr. Panagiotis Kastritis

Martin-Luther-Universität Halle-Wittenberg

Naturwissenschaftliche Fakultät I

Institut für Biochemie und Biotechnologie

Enzymopathies are genetic metabolic disorders due to missing or defective enzymes. Understanding enzyme structure, function, and interactions in their native cellular context is crucial. Enzymes in cells form metabolons, enhancing metabolic pathway efficiency. Grasping the molecular organization of these supercomplexes is challenging due to size and transience. Traditional structural biology methods illuminate individual enzymes but not their higher-order assembly and interfaces.

My research integrates structural, biophysical, biochemical, and biocomputational approaches to unravel the molecular architecture of metabolons, aiming to elucidate atomic-level mechanisms in cellular respiration. Ultimately, it offers insights into cell mechanisms, potentially explaining how protein subunits synchronize for specific functions. Supercomplexes offer new opportunities for targeted drug design by focusing on unique protein interfaces rather than individual subunit active sites.

Profil • Service


Since 2018

W1 Junior Professor, Martin Luther University of Halle-Wittenberg

Since 2018

Group leader, Interdisciplinary Research Center ZIKHALOmem, Martin-Luther University of Halle-Wittenberg


Postdoctoral Researcher, Structural and Computational Biology Unit, European Molecular Biology Laboratory-Heidelberg, Heidelberg, Germany


Postdoctoral Researcher, Bijvoet Center for Biomolecular Research, University of Utrecht, Utrecht, The Netherlands


PhD in Chemistry, University of Utrecht, The Netherlands


Graduate Student, NMR Spectroscopy Group, Bijvoet Center for Biomolecular Research, University of Utrecht, Utrecht, The Netherlands


Diploma (MSc degree) in Biology, University of Athens, Greece


Studies in Biology, University of Athens, Greece


  • Molecular Biophysics
  • Electron Cryo-microscopy
  • Computational Structural Biology
  • Biochemistry
  • Integrative Structural Biology


  • Electron cryo-microscopy of biomolecular complexes
  • Assistance in computational structural analysis of large biomolecular complexes

Forschergruppen • Projekte • Kooperationen



Die Daten werden geladen ...


  • Technische Universität Berlin, Prof. Dr. Juri Rappsilber
  • University of Vienna, Prof. Dr. Lea Ann Dailey
  • University of Tennessee, Prof. Dr. Barry Bruce
  • University of L'Aquila, Dr. Claudio Iacobucci
  • Centro Nacional de Biotecnologia (CNB-CSIC), Prof. José María Carazo
  • Izmir Biomedicine and Genome Center, Ass. Prof. Dr. Ezgi Karaca
  • Max Planck Institute of Colloids and Interfaces, Dr. Rumiana Dimova
  • University of Graz, Prof. Dr. Sandro Keller
  • BioTechMed-Graz, Prof. Sandro Keller
  • Max Planck Institute for Dynamics of Complex Technical Systems, Prof. Dr. Kai Sundmacher
  • European Molecular Biology Laboratory (Hamburg), Dr. Jan Kosinski
  • National Hallenic Research Foundation, Athens, Dr. Christos Chochos
  • National Cancer Institute (NCI), NIH, Dr. Francis O' Reilly
  • Center for Structural Mass Spectrometry, Prof. Andrea Sinz
  • University of Patras, Prof. Dr. Georgios Spyroulias
  • BSRC Alexander Flemming, Dr. Georgios Skretas
  • Utrecht University, Prof. Dr. Alexandre Bonvin
  • Leibniz Institut für Pflanzenbiochemie, Prof. Dr. Alain Tissier
  • University of Geneva, Prof. Dr. Robbie Loewith
  • Palacky University, Dr. Roman Kouřil
  • RGCC International GmbH, Zug, Dr. Ioannis Papasotiriou
  • University of Regensburg, Prof. Dr. Christine Ziegler
  • TU Braunschweig, Prof. Dr. Tobias Kruse
  • Leibniz Institute of Plant Genetics and Crop Plant Research
  • Imperial College, Dr. Thodoris Karamanos
  • University of Manchester, Prof. Dr. Christos Pliotas
  • National and Kapodistrian University of Athens, Prof. Dr. Costas Vorgias
  • German Centre for Integrative Biodiversity Research (iDiv), Prof. Dr. Marcel Quint
  • Leipzig University Medical School, Dr. Georg Künze