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DDX3 RNA helicases: IDRs that integrate RNA granule dynamics with cytoplasmic gene expression regulation

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Deutsche Forschungsgemeinschaft (DFG) ;
The DDX3 RNA helicase, LAF-1, contains two large, intrinsically disordered regions (IDRs), and associates with microscopically visible, germ cell-specific ribonucleoprotein particles (P granules) in the developing C. elegans embryo. The content of LAF-1-containing granules and their mode of mRNA regulation will be investigated within RTG2467.

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