Innovationsportal Sachsen-Anhalt

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2000-2006   Bilinguales Abitur, Ubbo-Emmius-Gymnasium Leer: Biologie, Kunst, Englisch, Geographie Abschlussnote: 1,7     
2006-2013    Studium der Humanmedizin an der Medizinischen Hochschule Hannover (MHH) Abschlussnote: gut            
2010-2017    Promotion zum Dr. med.  am Institut für Musikermedizin und Musikphysiologie der HMTMH bei Prof. Dr. med. Eckart Altenmüller, Thema: „Structural neuroplasticity in expert pianists depends on the age of musical training onset“
                                                 Abschlussnote: magna cum laude
Jun 2021        Facharzt für Neurochirurgie

Mai 2006       Humangenetik, Universität, Bremen
Spt 2007        Neurochirurgie, International Neuroscience Institute, Hannover
Mrz 2008      Unfallchirurgie, Nordstadt Klinikum, Hannover
Spt 2009        Psychosomatik, Campus Charité Mitte, Berlin
Apr 2010       Neurochirurgie, Rambam Health Care Campus, Haifa, Israel
Jul  2010        Neuroradiologie, Vivantes Krankenhaus Neukölln, Berlin
Spt 2010        Neurologie, Nordstadt Klinikum, Hannover
Jan 2020        Neurochirurgie, Hospital Calixto Garcia, Roberto Verdial, Havanna, Cuba
Jan 2020        Neurochirurgie, Clinico Hermanos Ameijeiras, Enrique de Jongh Cobo, Havanna, Cuba
Aug 2012       Hämatoonkologie, Knochenmarktransplantationsstation, Immunologie, MHH, Hannover
Dez 2012       Unfall-, Allgemein-, Visceral-, Gefäß- und Neurochirurgie, Nordstadt Klinikum, Hannover
Mrz 2013      Neurologie, Nordstadt Klinikum Hannover

Jun 11/Dez 12         Stations- und OP-Assistent, Traumatologie, Neustadt am Rübenberge
Aug 2013                   Sitzwache in der Psychiatrie Langenhagen, Hannover
seit Aug 2014           Assistenzarzt, Neurochirurgie, Nordstadt Klinikum, Hannover
                                     Direktor: Prof. Dr. med. I. E. Sandalcioglu, Prof. Dr. med. A. Nabavi
seit Aug 2014           Mitglied des neurochirurgischen Forschungslabors Nordstadt Klinikum Hannover; Abteilung Neuroimaging und 3D Visualisierung
                                     Direktorin: Dr. rer. nat. Claudia A. Dumitru
seit Jun 2020            Assistenzarzt der Universitätsklinik für Neurochirurgie, Universität Magdeburg, Deutschland
                                     Direktor: Prof. Dr. med. I. E. Sandalcioglu
seit Jun 2020            Leiter der Forschungsgruppe: Perioperative Adaption funktioneller Netzwerke sowie deren Einsatz zur Planung der neurochirurgischer Interventionen
seit Aug 2021           Oberarzt der Universitätsklinik für Neurochirurgie, Universität Magdeburg, Deutschland
                                     Direktor: Prof. Dr. med. I. E. Sandalcioglu

Feb 2017    Hartmann, K., Stein, K.-P., Neyazi, B., Sandalcioglu, I. E., Intraoperative optical coherance tomography in neurosurgical procedures: A new dynamic neuroimaging modality. 6th Congress of the Intra Operative Imaging Society. Hanover, Germany
Sept 2017    Hartmann, K. 2017. Auswirkungen intensives Klavierspielens auf die Hirnmorphologie. 16. Symposium der Deutschen Gesellschaft für Musikermedizin und Musikphysiologie. Oberwesel, Germany
Juni 2018    Hartmann, K. 2018. A View into the Plastic Architecture of the Human Brain - Structural Adaptations in High Level Pianists. 14. Kongress für Tanzmedizin. Frankfurt am Main, Germany.
Jan 2020       Hartmann, K.,  A Neuroscientific View on Music Evoked Emotions, Workshop, Panama
Sept 2016    Hartmann, K., Vaskuläre Anatomie des zentralen Nervensystems. Regelmäßiger  Studenten Unterricht im Rahmen des Wahlpflichtfaches: Neurochirurgie – Operative Anatomie. Lehrveranstaltung der Medizinischen Hochschule Hannover MHH
Jan 2021                                Neuroscience and Dance, Block Seminar, Postgraduate Master of Advanced Studies in Dance Science,  University of Bern      
seit Aug 2020                       Betreuung Doktoranden der Humanmedizin; Adaption funktioneller Netzwerke im Rahmen neurochirurgischer Krankheitsbilder
Aug 2017                             Wissenschaftspreis 2017 der Deutschen Gesellschaft für Musikermedizin und Musikphysiologie


Innovative Imaging Techniques for Neurosurgical Guidance
OCT imaging depends on the detection of back scattered near infrared light and is therefore harmless to biological tissue. Its physical properties allow for microscope integration. This leads to the possibility of contact free three-dimensional, real-time scanning of tissue in the field of view of the surgeon. Penetrating depth depends on optical tissue densities. With approximately 4000 µm in the human cerebral cortex it meets microsurgical requirements.
In particular OCT offers an unprecedented axial spatial resolution ranging from 1 - 15 µm –approaching the resolution of conventional histopathology. In vitro recent optical and image processing advancements like automatic serial sectioning of polarization sensitive OCT (asPSOCT) and speckle modulation further increased image quality to display cerebral cortical layers at single cell width.
A part from structural imaging adaptations of perfusion-dependent OCT offer the possibility of parallel functional brain mapping. Due to the capability of performing “optic biopsies” systems which combine catheter integrated OCT and laser ablation might demonstrate minimal invasive and precise theranostic instruments.
These versatile strengths shed light on future perspectives. Our team validates intraoperative use of microscope integrated OCT for progression of neurosurgical guidance.

Perioperative Adaptions of Functional Brain Networks [EN]
Brainfunction is based on the integrity of functional brain networks. Impairements of functional brain networks manifest in neurological deficits.
During our clinical routine we already use high resolution, contrast enhanced, perfusion- and diffusion based as well as task based magnet resonance imaging to delineate structural and functional correlates of neurological deficits. Measurements of spontanous activity at rest to delineate functional brain networks are missing so far. Though they now state a the only technique to delineate functional brain networks.
During recent years resting state functional brain imaging gained importance for clinical applications in diseases like Autism, Schizophrenia, Alzheimer or Parkinson’s (Fox and Greicius et al. 2010). E g. in ADHS-Syndrom decreased functional connectivity of ACC (anterior cingulate cortex) and PCC (posterior cingulate cortex) could be described (Castellanos et al. 2008). The relevance of this technique as an objective diagnostic measurement is object of research.
Another future application is the delineation of eloquent brain areas for neurosurgical guidance. Up to date tasked based fMRI is used to delineate these - often individual or pathological relocated - brain areas (Petrella et al. 2006). In unconscious, impaired or pediatric patients task based approaches are limited. We here test for the relevance of resting state brain networks for the delineation of otherwise concealed eloquent brain networks (Nandakumar et al. 2019).