« Forschungslandschaft: Projekte
Wavelike dynamics in neocortical networks for cognitive control (SFB 1436 - C05 - Krug, Ritter)
Projektleiter:
Projektbearbeiter:
Prof. Dr. med. Petra Ritter,
Amy Addlesee,
Prof. Dr. Dr. Andrew Parker,
Dr. Sascha Ziegler
Projekthomepage:
Finanzierung:
Forschergruppen:
The electrical activity of primate cortex shows patterns of travelling waves and frequency gradients in
many regions. This dynamic activity has been found across various frequency bands, spatial scales and
neuroimaging modalities, e.g. voltage-sensitive dye, local field potentials (LFPs), M/EEG, and fMRI.
Recent work suggests that cortical travelling waves within small zones of cortex might be an important
neural mechanism for cognitive function but also argues that traditional analysis techniques may be
inadequate to reveal these functions. Emerging research shows a direct link between the timing of these
wavelike signals within visual cortical area V5/MT in the primate and cognitive task performance, although fundamental questions remain concerning how neural computation is performed in the
presence of physiological wave-like events. Linking the more global, inter-areal waves observed to these
local wave patterns will open up a new insight into the control of cognitive function through cognitive
resource allocation.
In the first CRC funding phase, we hypothesized and confirmed that brain functional connectivity shapes cognitive performance. With computational brain network modeling, we identified the theoretical principles underlying this relationship. We also characterized the detailed structural and functional circuits of brain nodes central to perceptual decision-making in primates. In the second CRC phase, we plan to investigate the dynamics of travelling waves and frequency gradients that give rise to cognitive function and variability in this network - again combining experiments and computational modeling. Specifically, we plan to investigate how effective connectivity shapes both phenomena by directing cortical travelling waves within the decision-making network, shaping them within cortical areas and generating effective frequency gradients between cortical areas during task performance. We will build on experimental and modelling work performed in phase 1, concentrating on the primate perceptual
decision-making network in V5/MT and its connections, because work in this area in a different primate
species has discovered how travelling waves affect cognitive performance. First, by fitting our cortical network model to functional connectivity, we will investigate the causal link between effective connectivity, travelling wave direction, frequency gradients and cognitive resource allocation. Second, we will test experimentally whether specific effective frequency patterns of activation co-emerge with directed travelling waves. Lastly, our subproject will probe directly the relationship between travelling waves, neural dynamics and cogntive performance through modelling and direct intervention.
Thus, we will link intra-areal waves to network wide cortical waves and seek to test the theoretical position that the strength and pattern of the incoming connectivity shape cognitive performance by directing travelling waves and effective frequency gradients.
many regions. This dynamic activity has been found across various frequency bands, spatial scales and
neuroimaging modalities, e.g. voltage-sensitive dye, local field potentials (LFPs), M/EEG, and fMRI.
Recent work suggests that cortical travelling waves within small zones of cortex might be an important
neural mechanism for cognitive function but also argues that traditional analysis techniques may be
inadequate to reveal these functions. Emerging research shows a direct link between the timing of these
wavelike signals within visual cortical area V5/MT in the primate and cognitive task performance, although fundamental questions remain concerning how neural computation is performed in the
presence of physiological wave-like events. Linking the more global, inter-areal waves observed to these
local wave patterns will open up a new insight into the control of cognitive function through cognitive
resource allocation.
In the first CRC funding phase, we hypothesized and confirmed that brain functional connectivity shapes cognitive performance. With computational brain network modeling, we identified the theoretical principles underlying this relationship. We also characterized the detailed structural and functional circuits of brain nodes central to perceptual decision-making in primates. In the second CRC phase, we plan to investigate the dynamics of travelling waves and frequency gradients that give rise to cognitive function and variability in this network - again combining experiments and computational modeling. Specifically, we plan to investigate how effective connectivity shapes both phenomena by directing cortical travelling waves within the decision-making network, shaping them within cortical areas and generating effective frequency gradients between cortical areas during task performance. We will build on experimental and modelling work performed in phase 1, concentrating on the primate perceptual
decision-making network in V5/MT and its connections, because work in this area in a different primate
species has discovered how travelling waves affect cognitive performance. First, by fitting our cortical network model to functional connectivity, we will investigate the causal link between effective connectivity, travelling wave direction, frequency gradients and cognitive resource allocation. Second, we will test experimentally whether specific effective frequency patterns of activation co-emerge with directed travelling waves. Lastly, our subproject will probe directly the relationship between travelling waves, neural dynamics and cogntive performance through modelling and direct intervention.
Thus, we will link intra-areal waves to network wide cortical waves and seek to test the theoretical position that the strength and pattern of the incoming connectivity shape cognitive performance by directing travelling waves and effective frequency gradients.
Kontakt
Prof. Dr. Kristine Krug
Otto-von-Guericke-Universität Magdeburg
Fakultät für Naturwissenschaften
Institut für Biologie
Leipziger Str. 44
39120
Magdeburg
Tel.:+49 391 6755051
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